Source:GMATPrep

The investigations of many psychologist and anthropologists support the generalization of there being little that is a significant difference in underlying mental processes manifested by people from different culture.
A of there being little that is a significant difference
B of there being little that is significantly different
C of little that is significantly different
D that there is little that is significantly different
E that there is little of significant differences

How to pick between D and E

little of significant differences (plural seems awkward).
This clearly is wrong

Idiomatic usage. In the phrase 'little of X', the X has to be a singular quantity. If it's plural (like 'differences'), then you have to use few.
There was very little food left over at the end of the party.
There were very few crab cakes left over at the end of the party.

Hope that helps.

What all errors are in options "A" and "B". Thanks

To the original poster (and everyone who posts questions): please be very careful in your transcription of the problem. Please also proofread when you're done typing but before you post. Every word (and even letter) counts! We want to make sure that we're studying these exactly as written because little typos can sometimes make big differences to the interpretation.

On to A and B. More idioms! we "support the generalization that" something is so, not "of" - so A, B, and C are all wrong for that reason. A and B also contain "being" - which, while it can be used grammatically correctly, is almost always wrong on the GMAT. (There's one GMATPrep question that uses "being" correctly. One. :)